June 05, 2015

Minimising the risk of fatal and non-fatal injury in jump racing

Dr Richard Reardon, Mr Anthony Stirk, Prof. Dominic Mellor, Dr Lisa Boden, Dr Richard Newton, Prof. Sandy Love, Dr Tim Parkin

Identification of modifiable risk factors for injury in jump racing Thoroughbreds

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April 24, 2015

A combined engineering and molecular approach to study the initiation and progression of equine tendinopathy

Prof Peter Clegg, Dr Hazel Screen, Dr Chavaunne Thorpe, Dr Helen Birch, Dr Graham Riley

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February 23, 2015

The behaviour of horse Toll-like receptors

Dr Kate Irvine 

A study designed to investigate the behaviour of specific horse immune receptors, and how their activity may be changed with drugs.

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January 29, 2015

New Research Projects

To Start in 2015

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December 08, 2014

Large Colon Torsion in the Horse

Joanna Suthers  

Risk factors for large colon torsion and survival following surgical treatment of this potentially fatal disease 

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October 23, 2014

Further development of a diagnostic blood test for larval stages of small redworm

Professor Jacqui Matthews 

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September 05, 2014

An extensive investigation into parasite control practices, the parasites present and their dewormer sensitivity on UK Thoroughbreds studs

Professor Jacqui Matthews 

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July 10, 2014

Streptococcus zooepidemicus bet hedging 
and equine respiratory disease 

Dr Andrew Waller and Professor Josh Slater

Making the most of an opportunity to cause disease.

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May 07, 2014

An investigation of the building blocks (mucins) of lung mucus in horses with Recurrent Airway Obstruction

Adele Williams

An exploration of the properties and sites of production of lung mucus, which is in excess and blocks the airways, in horses with heaves.

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February 10, 2014

Effects of athletic training on the equine heart: 
Do horses with big hearts run faster?

Lesley E Young, Katherine Rogers and James LN Wood

Heart size matters
HBLB funded research showed that if a racehorse, especially a jumper, has a large heart, it has a significant advantage due to superior oxygen supply. Eclipse, Phar Lap and Secretariat all had large hearts.

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February 08, 2014

Reprogramming of equine fibroblasts into
induced pluripotent stem cells (iPSCs) 

Dr F Xavier Donadeu

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February 07, 2014

Non-invasive monitoring of changes in exhaled markers of airway
inflammation in Thoroughbred racehorses

Michael P. Cathcart

Inflammatory Airway Disease (IAD)
IAD is of major significance to the Thoroughbred racehorse, with between 11-50% of young racehorses affected with the condition. The disease is associated with inflammation of the lungs and can cause significant exercise intolerance. The development of a non-invasive modality by which IAD can be diagnosed may help to improve performance and productivity and increase welfare, amoungst other things. 

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January 31, 2014

New Research Projects

To Start in 2014

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December 18, 2013

The Equine Infectious Disease Service
A 'Thoroughbred' Contribution to the nation's equine health

Dr Richard Newton, Animal Health Trust 

The Equine Infectious Disease Service at the Animal Health Trust has been supported by the HBLB since April 2008, via a collaborative funding arrangement with the Racehorse Owners Association (ROA) and the Thoroughbred Breeder's Association (TBA). The primary aim of the service is to provide the UK Thoroughbred industry with a first-class diagnostic surveillance facility for new and emerging equine diseases. 

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October 28, 2013

Sudden death in racing Thoroughbreds

Catriona Lyle and Bruce McGorum

Sudden death affects all equestrian sports with well-publicised examples from racing, eventing, show-jumping and hunting. HBLB funded research has helped to identify causes, risk factors and prevalence for this poorly understood and sensitive subject. 

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September 30, 2013

Equine Influenza Programme
Animal Health Trust

Neil Bryant, Adam Rash, Alana Woodward,
 Donna Blinman, Richard Newton, Debra Elton 

Equine Influenza is constantly present in the UK and is a major cause of respiratory disease in horse populations. This ongoing programme collects data for influenza viruses circulating in the UK and further afield to help keep vaccine strain recommendations up to date in a bid to prevent future outbreaks. 

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September 04, 2013

HBLB research leads the field in Equine Veterinary Journal 

E.E. Godwin; P. Clegg; C. Marr; Edited by C. Marr

Equine Veterinary Journal
HBLB funds around 10% of the veterinary research published in the world's leading scientific journal, with a study investigating stem cell therapy, funded by the HBLB, having the highest number of downloads for 2012.

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July 16, 2013

The Genetics of Tendon Injuries in Thoroughbreds

Lucinda Tully

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May 30, 2013

Jetlag in horses: Neuroendocrine mechanisms underlying effects of transmeridian flying on equine welfare and physiology

Domingo Tortonese, Julie Townsend, Cathy Fuller,
Twink Allen and Roger Short

International Jet Set
HBLB funded research has shown that horses, unlike humans, don’t suffer from ‘jet-lag’. They can actually show improved performance following some time zone shifts.

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Also see the article in our In The Press section on this website 

April 15, 2013

Evaluation of muscle calcium regulation in 
recurrent exertional rhabdomyolysis 
using a cell culture model derived from equine skin 

Dr Richard J Piercy 

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March 15, 2013

The role of MMP-1 in equine sarcoids 
- a potential therapeutic target? 

Professor Lubna Nasir 

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February 08, 2013

The role of platelet activation in
antimicrobial host defence

IĆ­lknur Aktan, Bettina Dunkel
& Fiona Cunningham

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December 13, 2012

Resource development to maximise effective control
of an outbreak of African Horse Sickness in Great Britain

Dr Richard Newton

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November 09, 2012

A Genome-wide association study of
osteochondritis dissecans  in the Thoroughbred

Laura Corbin, Sarah Blott, June Swinburne, Charlene Sibbons, Laura Fox-Clipsham, Maud Helwegen Tim Parkin, Richard Newton, Lawrence Bramlage, Wayne McIlwraith, Stephen Bishop, John Woolliams, Mark Vaudin

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October 01, 2012


New Research Projects

Funded in 2012 grant round

View details here
Photo courtesy of Mirrorpix
Assessing the effect of cardiac murmurs on performance

LE Young, K Rogers and JLN Wood

Heart murmurs: surely that can’t be good?
Heart murmurs, once considered a significant sign of heart problems, were shown by HBLB funded research to be common (50% of racehorses have them) and, in most cases, of no significance.

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National Hunt racehorse inflammatory airway disease: associations with bacteria, viruses, age, time in training and transferrin types
JR Newton, JLN Wood, KC Smith and JC Cardwell

When is 'the virus' not a virus?
HBLB funded research proved for the first time that most outbreaks of 'the virus' in training yards are actually associated with bacterial lung infections, which unlike viral illnesses, can be treated effectively.

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Injuries to National Hunt racehorses

Kristien Verheyen, Jo Price,
Roger Smith, James Wood, Elizabeth Ely

Injury types change as career progresses
The risk of different types of injury changes as horses' careers develop. HBLB funded research identifying and understanding these risks will help to develop practical advice and guidelines for trainers.

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September 28, 2012

September 04, 2012

Fat and foul, foal fiends: The role of fatty acid and cholesterol catabolism in the pathogenesis of Rhodococcus equi

Dr Sharon Kendall
Royal Veterinary College

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Studies to minimise the risk of fatal and non-fatal injury in jump racing

Dr Tim Parkin
      University of Glasgow

     View presentation here
The importance of Streptococcus zooepidemicus surface protein SZO08560 in attachment and/or invasion of the equine respiratory tract

Dr Andrew Waller
Animal Health Trust

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A combined engineering and molecular approach to study the initiation and progression of equine tendinopathy

 Professor Peter Clegg
        University of Liverpool

       View presentation here
Functional analysis of the Rhodococcus equi genome

 Professor Jose Vazquez-Boland
        University of Edinburgh

        View presentation here
An investigation into the current status of anthelmintic resistance in breeding Thoroughbreds in the UK

 Professor Jacqui Matthews
        Moredun Research Institute

      View presentation here
Further development of a diagnostic immunoassay for larval cyathostomins

Professor Jacqui Matthews
Moredun Research Institute

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Photo Courtesy of the Mirrorpix
Horserace Betting Levy Board research funding 2000 – 2010

Equine musculoskeletal sciences

 Summary by Rob Pilsworth
HBLB’s Veterinary Advisory Committee

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Horserace Betting Levy Board research funding 1998 – 2010

Equine genetics

 Summary by Celia Marr
HBLB’s Veterinary Advisory Committee

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Horserace Betting Levy Board research funding 1998 – 2010

Equine gastrointestinal parasites

 Summary by Chris Rea
HBLB’s Veterinary Advisory Committee

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Horserace Betting Levy Board research funding 1998 – 2010
Equine influenza

Summary by Celia Marr
HBLB’s Veterinary Advisory Committee

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Horserace Betting Levy Board research funding 1998 – 2010
Equine respiratory disease

Summary by Rob Pilsworth
HBLB’s Veterinary Advisory Committee

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Photo courtesy of the Racing Post

September 03, 2012

Sequencing of the Rhodococcus equi genome

The International Rhodococcus equi consortium (IREC)
Co-ordinator Prof Jose Vazquez-Boland

Addressing a global problem
Rhodococcus infection is a major killer of foals across the world. An international consortium led by British researchers and with funding from HBLB has documented the bacteria's genetic map, paving the way to future life-saving treatments and vaccines.

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Regenerating equine tendon using autologous mesenchymal stem cells

Roger K.W. Smith, Stephanie Dakin,
Natalie Young, Jayesh Dudhia,
Peter Clegg & Allen Goodship

Injured tendons can be as good as new
Tendons need to be strong and elastic. After injury, scar tissue can form within damaged tnedon and predisposes to further injury. In HBLB research treatment with stem cells led to regeneration of tendon with less scar tissue and more elasticity.

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Development of a diagnostic immunoassay for larval cyathostominosis

PI: Professor Jacqueline Matthews
Moredun Research Institute/University of Edinburgh
Co-Applicant: Dr Jane Hodgkinson, University of Liverpool
Researchers: Hamish McWilliam, Mairi Mitchell,  Samantha Dowdall

The worms have turned
Bacteria and parasites are constantly evolving ways to protect themselves against the drugs we use against them. Partnerships between scientists and Thoroughbred breeders are developing essential new approaches funded by HBLB for worm control.

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