February 10, 2014

Effects of athletic training on the equine heart: 
Do horses with big hearts run faster?

Lesley E Young, Katherine Rogers and James LN Wood


Heart size matters
HBLB funded research showed that if a racehorse, escpecially a jumper, has a large heart, it has a significant advantage due to superior oxygen supply. Eclipse, Phar Lap and Secretariat all had large hearts.

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February 08, 2014

Reprogramming of equine fibroblasts into
induced pluripotent stem cells (iPSCs) 

Dr F Xavier Donadeu

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February 07, 2014

Non-invasive monitoring of changes in exhaled markers of airway
inflammation in Thoroughbred racehorses

Michael P. Cathcart


Inflammatory Airway Disease (IAD)
IAD is of major significance to the Thoroughbred racehorse, with between 11-50% of young racehorses affected with the condition. The disease is associated with inflammation of the lungs and can cause significant exercise intolerance. The development of a non-invasive modality by which IAD can be diagnosed may help to improve performance and productivity and increase welfare, amoungst other things. 

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January 31, 2014

New Research Projects

To Start in 2014


View details here

December 18, 2013

The Equine Infectious Disease Service
A 'Thoroughbred' Contribution to the nation's equine health

Dr Richard Newton, Animal Health Trust 


The Equine Infectious Disease Service at the Animal Health Trust has been supported by the HBLB since April 2008, via a collaborative funding arrangement with the Racehorse Owners Association (ROA) and the Thoroughbred Breeder's Association (TBA). The primary aim of the service is to provide the UK Thoroughbred industry with a first-class diagnostic surveillance facility for new and emerging equine diseases. 

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October 28, 2013

Sudden death in racing Thoroughbreds

Catriona Lyle and Bruce McGorum




Sudden death affects all equestrian sports with well-publicised examples from racing, eventing, show-jumping and hunting. HBLB funded research has helped to identify causes, risk factors and prevalence for this poorly understood and sensitive subject. 

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September 30, 2013

Equine Influenza Programme
Animal Health Trust

Neil Bryant, Adam Rash, Alana Woodward,
 Donna Blinman, Richard Newton, Debra Elton 



Equine Influenza is constantly present in the UK and is a major cause of respiratory disease in horse populations. This ongoing programme collects data for influenza viruses circulating in the UK and further afield to help keep vaccine strain recommendations up to date in a bid to prevent future outbreaks. 

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September 04, 2013

HBLB research leads the field in Equine Veterinary Journal 

E.E. Godwin; P. Clegg; C. Marr; Edited by C. Marr



Equine Veterinary Journal
HBLB funds around 10% of the veterinary research published in the world's leading scientific journal, with a study investigating stem cell therapy, funded by the HBLB, having the highest number of downloads for 2012.

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July 16, 2013

The Genetics of Tendon Injuries in Thoroughbreds

Lucinda Tully

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May 30, 2013

Jetlag in horses: Neuroendocrine mechanisms underlying effects of transmeridian flying on equine welfare and physiology

Domingo Tortonese, Julie Townsend, Cathy Fuller,
Twink Allen and Roger Short



International Jet Set
HBLB funded research has shown that horses, unlike humans, don’t suffer from ‘jet-lag’. They can actually show improved performance following some time zone shifts.

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Also see the article in our In The Press section on this website 

April 15, 2013

Evaluation of muscle calcium regulation in 
recurrent exertional rhabdomyolysis 
using a cell culture model derived from equine skin 

Dr Richard J Piercy 

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March 15, 2013

The role of MMP-1 in equine sarcoids 
- a potential therapeutic target? 

Professor Lubna Nasir 

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February 08, 2013

The role of platelet activation in
antimicrobial host defence

IĆ­lknur Aktan, Bettina Dunkel
& Fiona Cunningham

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December 13, 2012

Resource development to maximise effective control
of an outbreak of African Horse Sickness in Great Britain

Dr Richard Newton

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November 09, 2012

 
A Genome-wide association study of
osteochondritis dissecans  in the Thoroughbred

Laura Corbin, Sarah Blott, June Swinburne, Charlene Sibbons, Laura Fox-Clipsham, Maud Helwegen Tim Parkin, Richard Newton, Lawrence Bramlage, Wayne McIlwraith, Stephen Bishop, John Woolliams, Mark Vaudin

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October 01, 2012



 

New Research Projects

Funded in 2012 grant round


View details here
Photo courtesy of Mirrorpix
Assessing the effect of cardiac murmurs on performance

LE Young, K Rogers and JLN Wood


Heart murmurs: surely that can’t be good?
Heart murmurs, once considered a significant sign of heart problems, were shown by HBLB funded research to be common (50% of racehorses have them) and, in most cases, of no significance.


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National Hunt racehorse inflammatory airway disease: associations with bacteria, viruses, age, time in training and transferrin types
JR Newton, JLN Wood, KC Smith and JC Cardwell


When is 'the virus' not a virus?
HBLB funded research proved for the first time that most outbreaks of 'the virus' in training yards are actually associated with bacterial lung infections, which unlike viral illnesses, can be treated effectively.

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Injuries to National Hunt racehorses

Kristien Verheyen, Jo Price,
Roger Smith, James Wood, Elizabeth Ely


Injury types change as career progresses
The risk of different types of injury changes as horses' careers develop. HBLB funded research identifying and understanding these risks will help to develop practical advice and guidelines for trainers.

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September 28, 2012

September 04, 2012

Fat and foul, foal fiends: The role of fatty acid and cholesterol catabolism in the pathogenesis of Rhodococcus equi

Dr Sharon Kendall
Royal Veterinary College

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Studies to minimise the risk of fatal and non-fatal injury in jump racing

Dr Tim Parkin
      University of Glasgow

     View presentation here
The importance of Streptococcus zooepidemicus surface protein SZO08560 in attachment and/or invasion of the equine respiratory tract

Dr Andrew Waller
Animal Health Trust

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A combined engineering and molecular approach to study the initiation and progression of equine tendinopathy

 Professor Peter Clegg
        University of Liverpool

       View presentation here
Functional analysis of the Rhodococcus equi genome

 Professor Jose Vazquez-Boland
        University of Edinburgh

        View presentation here
An investigation into the current status of anthelmintic resistance in breeding Thoroughbreds in the UK

 Professor Jacqui Matthews
        Moredun Research Institute

      View presentation here
Further development of a diagnostic immunoassay for larval cyathostomins

Professor Jacqui Matthews
Moredun Research Institute

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Photo Courtesy of the Mirrorpix
Horserace Betting Levy Board research funding 2000 – 2010

Equine musculoskeletal sciences

 Summary by Rob Pilsworth
HBLB’s Veterinary Advisory Committee

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Horserace Betting Levy Board research funding 1998 – 2010

Equine genetics

 Summary by Celia Marr
HBLB’s Veterinary Advisory Committee

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Horserace Betting Levy Board research funding 1998 – 2010

Equine gastrointestinal parasites

 Summary by Chris Rea
HBLB’s Veterinary Advisory Committee

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Horserace Betting Levy Board research funding 1998 – 2010
 
Equine influenza

Summary by Celia Marr
HBLB’s Veterinary Advisory Committee

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Horserace Betting Levy Board research funding 1998 – 2010
 
Equine respiratory disease

Summary by Rob Pilsworth
HBLB’s Veterinary Advisory Committee

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Photo courtesy of the Racing Post

September 03, 2012

Sequencing of the Rhodococcus equi genome

The International Rhodococcus equi consortium (IREC)
Co-ordinator Prof Jose Vazquez-Boland



Addressing a global problem
Rhodococcus infection is a major killer of foals across the world. An international consortium led by British researchers and with funding from HBLB has documented the bacteria's genetic map, paving the way to future life-saving treatments and vaccines.

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Regenerating equine tendon using autologous mesenchymal stem cells

Roger K.W. Smith, Stephanie Dakin,
Natalie Young, Jayesh Dudhia,
Peter Clegg & Allen Goodship
 

Injured tendons can be as good as new
Tendons need to be strong and elastic. After injury, scar tissue can form within damaged tnedon and predisposes to further injury. In HBLB research treatment with stem cells led to regeneration of tendon with less scar tissue and more elasticity.

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Development of a diagnostic immunoassay for larval cyathostominosis

PI: Professor Jacqueline Matthews
Moredun Research Institute/University of Edinburgh
Co-Applicant: Dr Jane Hodgkinson, University of Liverpool
Researchers: Hamish McWilliam, Mairi Mitchell,  Samantha Dowdall


The worms have turned
Bacteria and parasites are constantly evolving ways to protect themselves against the drugs we use against them. Partnerships between scientists and Thoroughbred breeders are developing essential new approaches funded by HBLB for worm control.

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Developing a laboratory model of Setfast in Thoroughbreds by converting skin-derived cells into muscle cells

Marta Fernandez-Fuente,  Richard J. Piercy et al.
Comparative Neuromuscular Diseases Laboratory
Royal Veterinary College

High tech science for an age-old problem
Ste fast, or tying up, has plagued horses for centuries. Using the latest cell biology techniques, scientists with HBLB funding are finding out more about muscle cells by manipulating skin cells to behave like muscles.

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CT and MRI detectable markers for condylar fracture

Tim Parkin – University of Glasgow
Rachel Murray & Carolyne Tranquille – Animal Health Trust
Kenton Morgan & Jen Swindlehurst – University of Liverpool
Wayne McIlwraith, Chris Kawcak & Chelsea Zimmerman – Colorado State University


Preventing cannon bone fractures
MRI scans detect changes which simply don't show on normal x-rays BEFORE the bone breaks. HBLB funded research has identified clear tell tale changeswhich predict a horse is 'at risk'. In this way cannon bone fractures, the injury that ended the racing career of Mill Reef, Manduro, Dubai Millennium and others, may soon become less frequent.

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