Effects of athletic training on the equine heart: Do horses with big hearts run faster?
Lesley E Young, Katherine Rogers and James LN Wood
Heart size matters HBLB funded research showed that if a racehorse, escpecially a jumper, has a large heart, it has a significant advantage due to superior oxygen supply. Eclipse, Phar Lap and Secretariat all had large hearts.
Non-invasive monitoring of changes in exhaled markers of airway
inflammation in Thoroughbred racehorses
Michael P. Cathcart
Inflammatory Airway Disease (IAD) IAD is of major significance to the Thoroughbred racehorse, with between 11-50% of young racehorses affected with the condition. The disease is associated with inflammation of the lungs and can cause significant exercise intolerance. The development of a non-invasive modality by which IAD can be diagnosed may help to improve performance and productivity and increase welfare, amoungst other things.
The Equine Infectious Disease Service A 'Thoroughbred' Contribution to the nation's equine health
Dr Richard Newton, Animal Health Trust
The Equine Infectious Disease Service at the Animal Health Trust has been supported by the HBLB since April 2008, via a collaborative funding arrangement with the Racehorse Owners Association (ROA) and the Thoroughbred Breeder's Association (TBA). The primary aim of the service is to provide the UK Thoroughbred industry with a first-class diagnostic surveillance facility for new and emerging equine diseases.
Sudden death affects all equestrian sports with well-publicised examples from racing, eventing, show-jumping and hunting. HBLB funded research has helped to identify causes, risk factors and prevalence for this poorly understood and sensitive subject.
Equine Influenza is constantly present in the UK and is a major cause of respiratory disease in horse populations. This ongoing programme collects data for influenza viruses circulating in the UK and further afield to help keep vaccine strain recommendations up to date in a bid to prevent future outbreaks.
HBLB research leads the field in Equine Veterinary Journal
E.E. Godwin; P. Clegg; C. Marr; Edited by C. Marr
Equine Veterinary Journal
HBLB funds around 10% of the veterinary research published in the world's leading scientific journal, with a study investigating stem cell therapy, funded by the HBLB, having the highest number of downloads for 2012.
A Genome-wide association study of osteochondritis dissecans in the Thoroughbred
Laura Corbin, Sarah Blott, June Swinburne, Charlene Sibbons, Laura Fox-Clipsham, Maud Helwegen Tim Parkin, Richard Newton, Lawrence Bramlage, Wayne McIlwraith, Stephen Bishop, John Woolliams, Mark Vaudin
Assessing the effect of cardiac murmurs on performance
LE Young, K Rogers and JLN Wood
Heart murmurs: surely that can’t be good? Heart murmurs, once considered a significant sign of heart
problems, were shown by HBLB funded research to be common (50% of racehorseshave them)
and, in most cases, of no significance.
National Hunt racehorse inflammatory airway disease: associations with bacteria, viruses, age, time in training and transferrin types
JR Newton, JLN Wood, KC Smith and JC Cardwell
When is 'the virus' not a virus? HBLB funded research proved for the first time that most outbreaks of 'the virus' in training yards are actually associated with bacterial lung infections, which unlike viral illnesses, can be treated effectively.
The risk of different types of injury changes as horses' careers develop. HBLB funded research identifying and understanding these risks will help to develop practical advice and guidelines for trainers.
The International Rhodococcus equi consortium (IREC)
Co-ordinator Prof Jose Vazquez-Boland
Addressing a global problem
Rhodococcus infection is a major killer of foals across the world. An international consortium led by British researchers and with funding from HBLB has documented the bacteria's genetic map, paving the way to future life-saving treatments and vaccines.
Regenerating equine tendon using autologous mesenchymal stem cells
Roger K.W. Smith, Stephanie Dakin,
Natalie Young, Jayesh Dudhia, Peter Clegg & Allen Goodship
Injured tendons can be as good as new Tendons need to be strong and elastic. After injury, scar tissue can form within damaged tnedon and predisposes to further injury. In HBLB research treatment with stem cells led to regeneration of tendon with less scar tissue and more elasticity.
Bacteria and parasites are constantly evolving ways to protect themselves against the drugs we use against them. Partnerships between scientists and Thoroughbred breeders are developing essential new approaches funded by HBLB for worm control.
Developing a laboratory model of Setfast in Thoroughbreds by converting skin-derived cells into muscle cells
Marta Fernandez-Fuente,Richard J. Piercy et al.
Comparative Neuromuscular Diseases Laboratory
Royal Veterinary College
High tech science for an age-old problem Ste fast, or tying up, has plagued horses for centuries. Using the latest cell biology techniques, scientists with HBLB funding are finding out more about muscle cells by manipulating skin cells to behave like muscles.
CT and MRI detectable markers for condylar fracture
Tim Parkin – University of Glasgow
Rachel Murray & CarolyneTranquille – Animal Health Trust
Kenton Morgan & Jen Swindlehurst – University of Liverpool
Wayne McIlwraith, Chris Kawcak & Chelsea Zimmerman – Colorado State University
Preventing cannon bone fractures
MRI scans detect changes which simply don't show on normal x-rays BEFORE the bone breaks. HBLB funded research has identified clear tell tale changeswhich predict a horse is 'at risk'. In this way cannon bone fractures, the injury that ended the racing career of Mill Reef, Manduro, Dubai Millennium and others, may soon become less frequent.